Jing Qi1, Amita Shukla-Dave1,
Jason Koutcher1, Mithat Gnen2, Yuman Fong3,
1Medical Physics, Memorial Sloan-Kettering Cancer Center; 2Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center; 3Surgery, Memorial Sloan-Kettering Cancer Center; 4Radiology, Sloan-Kettering Cancer Center; 5Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States
In order to evaluate reproducibility of liver metabolites measured by 1H decoupled-31P MRSI technique, 13 normal subjects were investigated twice at 2 weeks interval. Concentration of PE, PC, PME, Pi, GPE, GPC, PDE and NTP were calculated. Inter- and intra- subject variations were analyzed. Inter- and intra-subject coefficient variation ranged from 11% to 25 % for all metabolite concentration. Intra-subject reproducibility was not superior to inter-subject reproducibility, indicating that the random biological differences dont seem to exceed the differences generated by technical variation in normal volunteers. Both technical and biological factors should be considered when interpret liver 31P MRSI data.