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Abstract #2659

MRI and MRS Monitoring of Gastrointestinal Distribution, Physiological Effects and Absorption of Fat Emulsions

Mahamoud Omar Hussein1, Luca Marciani2, Mary Stephenson1, Caroline L. Hoad1, Eleanor F. Cox1, Elisa Placidi1, Susan Pritchard1, Henelyta Ribeiro3, Elisabetta Ciampi3, Pip Rayment3, Asish Nandi3, Nick Hedges3, Paul Sanderson3, Irmela Kruse3, Robin C. Spiller2, Penny A. Gowland1

1The Sir Peter Mansfied Magnetic Resonance Centre, School of Physics & Astronomy, The University of Nottingham, Nottingham, NG7 2RD, United Kingdom; 2Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, The University of Nottingham, Nottingham, United Kingdom; 3Unilever Discover, Colworth Science Park, Bedford, United Kingdom

MRI can monitor gastrointestinal function and visualise the water and fat components of food in the gut separately. This study describes development work aimed to combine MRI and MRS to provide a method of monitoring the gastrointestinal fate and absorption of fat in the skeletal muscle and liver. Two healthy volunteers were fed two fat emulsions of different droplet sizes and were scanned at intervals postprandially. The 2 different meals triggered a diverse duodenal response affecting gastric emptying, gallbladder contraction and small bowel secretion. MRS showed promise for monitoring changes in both liver and calf lipid/water ratios.