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Abstract #2669

Using DCE-MRI to Determine Vascular Properties of Female Rhesus Macaque Reproductive Tissue: Pharmacokinetic Model Considerations

Ian J. Tagge1, Cecily V. Bishop2, Richard L. Stouffer2,3, Charles S. Springer, Jr. 1, Xin Li1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Division of Reproductive Sciences, ONPRC, Oregon Health & Science University; 3Department of Obstetrics and Gynecology, Oregon Health & Science University

The female uterus and ovary are among the few normal tissues to undergo periodic angiogenic changes. Using a primate model (rhesus macaque), we investigate the feasibility of DCE-MRI to quantify blood volume fraction (vb) and contrast reagent (CR) transendothelial permeability. The standard model with vb (SM2) and the second generation shutter-speed model (SSM2), are used in parallel for this effort.