Andrew L. Wentland1,2, Nathan S. Artz1,
Arjang Djamali3, Thomas M. Grist1,2, Sean B. Fain1,
Elizabeth A. Sadowski2
1Medical Physics, University of
Wisconsin School of Medicine & Public Health, Madison, WI, United States;
2Radiology, University of Wisconsin School of Medicine &
Public Health, Madison, WI, United States; 3Nephrology, University
of Wisconsin School of Medicine & Public Health, Madison, WI, United
States
Given
the recent link between nephrogenic systemic fibrosis and gadolinium-based
contrast agents (GBCAs), it has become increasingly important to evaluate
techniques that operate independently of GBCAs. In this study, measurements
of perfusion, oxygenation, and total renal blood flow (TRBF) were acquired in
swine with arterial spin labeling-based perfusion, BOLD MRI, and phase
contrast MRI, respectively. Scans were repeated during a state of increased
blood flow with acetylcholine and also a state of decreased blood flow with
the anesthetic isoflurane over a two-hour period. Measurements successfully
demonstrated increased perfusion, oxygenation, and TRBF with acetylcholine,
and the opposite trend with isoflurane.
Keywords