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Abstract #2723

A Versatile 3 T Phantom for Intravoxel-Incoherent Motion (IVIM) Sensitization of Microvascular Flow

Gene Young Cho1, Eric E. Sigmund1, Sungheon Kim1, Jens H. Jensen1, Daniel K. Sodickson1

1Center for Biomedical Imaging, Radiology, NYU School of Medicine, New York, United States

Diffusion-weighted imaging (DWI) can be sensitized to both tissue structure and microvascular flow in tumors. Capillary networks can present intravoxel-incoherent motion (IVIM), creating a pseudodiffusion coefficient that tracks microvascular flow. A versatile flow phantom was constructed for IVIM validation in a full body 3T scanner. This system allows technique optimization for ongoing IVIM-based studies of in vivo tumor pathologies. Biexponential analysis of DWI showed an increase in pseudodiffusivity with increasing flow and a decrease with increased impedance, simulating relevant microvascular processes. Spatial mapping of the IVIM coefficients showed strong contrast between pseudodiffusion and background diffusion. Future applications are discussed.