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Abstract #2724

Study on Effect of Water Exchange in Dynamic Contrast Enhanced MRI and Pharmacokinetic Model Analysis

Jin Zhang1, Sungheon Kim2

1Department of Finance and Risk Engineering, Polytechnic Institute of New York University, New York, NY, United States; 2Center for Biomedical Imaging, Radiology, NYU School of Medicine, New York, NY, United States

Extracting physiologically relevant parameters from DCE-MRI data is still a challenging problem since the effect of contrast agent is indirectly measured in proton MRI. The purpose of the current study was to use a numerical simulation method to generate DCE-MRI data with water exchange effect and to investigate its effects on the pharmacokinetic model parameters. Realistic MRI data were simulated using the BTEX model and a three-site two-exchange model. Two conventional pharmacokinetic models were fitted to the simulated data. The preliminary results demonstrate the significance of the water exchange effect in estimating pharmacokinetic model parameters.