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Abstract #2725

Selective Blood-Brain Barrier Permeabilization of F98 Rat Glioma to a High Molecular Weight Contrast Agent by an Inducible Kinin B1 Receptor Agonist

Jerome Cote1, Luc Tremblay1, Fernand Jr Gobeil2, David Fortin3, Martin Lepage1

1Nuclear medecine and radiobiology, Universit de Sherbrooke, Sherbrooke, QC, Canada; 2Pharmacology, Universit de Sherbrooke, Sherbrooke, QC, Canada; 3Surgery, Universit de Sherbrooke, Sherbrooke, QC, Canada

Dynamic contrast-enhanced magnetic resonance imaging with intravenous Gd-DTPA or Gadomer was used to monitor the selective increase of blood-brain barrier permeability (BBB) at the tumor of glioma-bearing rats, induced by either the natural kinin B1 receptor (B1R) agonist LDBK, or NG29, a synthetic high-affinity agonist. Post-contrast images revealed that only NG29 modulates topographic uptake profiles of both contrast agents within rat glioma and brain tissue surrounding the tumor, as observed by increase of both contrast agents distribution volume and mean Gd concentration in the implanted hemisphere. Our results confirm the use of B1R agonists to permeabilize the BBB around tumors.