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Abstract #2727

MRI T2* and T1 Ratio for Assessment of Transport of Macromolecular Contrast Agent in Tumor Interstitium

Ramesh Paudyal1, Hassan Bagher-Ebadian1,2, Swayamprava Panda1, Joseph D. Fenstemacher3, James R. Ewing1,2

1Neurology, Henry Ford Hospital, Detroit, MI, United States; 2Physics, Oakland University, Rochester, MI, United States; 3Anestheisology, Henry Ford Hospital, Detroit, MI, United States

Contrast-enhanced (CE-MRI) utilizes T1 and T2* contrast mechanism and paramagnetic labeled contrast agents (CAs) to characterize the resultant kinetic parameters of cerebral tissue. In this study, the dynamic maps of the ratio of T2* and T1, i.e.2 (the ratio of the relaxivities of T2* and T1), are employed to track the movement of the macromolecular CAs in tumors interstitium. The velocity wave fronts show the redistribution of CAs after extravasation in interstitium which allows monitoring the delivery of the chemotherapeutic agent in tissue