Anita
Banerji1,2, Josephine H. Naish1,2, Yvon Watson1,2,
Giovanni A. Buonaccorsi1,2, Geoff J. Parker1,2
1Imaging Sciences and Biomedical
Engineering, School of Cancer and Imaging Sciences, The University of
Manchester, Manchester, United Kingdom; 2Biomedical Imaging
Institute, Manchester, United Kingdom
Healthy
liver tissue has highly leaky sinusoids, a dual blood supply and can be
characterised using the one-compartment dual-input Materne model, whereas the
two-compartment single-input extended Kety model is often used to describe
tumours that contain capillaries and have an arterial supply. We use the
Akaike model selection criterion applied to dynamic contrast-enhanced MR data
of liver tumours. We demonstrate that the extended Kety model is preferred
within the tumour with a trend towards the Materne model within non-tumour
liver tissue. This has implications for the identification of tumours in the
liver and for partial volume errors.
Keywords