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Abstract #2739

In Vivo Measurement of Pharmacokinetic Parameters in Small Animal DCE-MRI Using Cardiac Sampling of the Vascular Input Function

Dustin K. Ragan1, Stephen Yenzen Lai2, James A. Bankson1

1Department of Imaging Physics, M. D. Anderson Cancer Center, Houston, TX, United States; 2Department of Head and Neck Surgery, M. D. Anderson Cancer Center, Houston, TX, United States

Measurement of pharmacokinetic parameters in small animal models of cancer is a frequently-used tool in preclinical investigations of novel interventions. One source of uncertainty from these measurements arises from the challenges of quantifying the concentration time course of a contrast agent in blood. We have proposed performing this measurement in the heart, which allows reduced-artifact high temporal resolution sampling. A pilot study was performed in a thyroid tumor model comparing the inter-subject variation produced by cardiac sampling with conventional sampling in a local blood vessel, and found a large reduction in variation with the proposed approach.