Katherine L. Wright1, Nicole Seiberlich2,
Stephen R. Yutzy1, Raymond F. Muzic1,2, Mark A.
Griswold1,2, Vikas Gulani2
1Department of Biomedical Engineering,
Case Western Reserve University, Cleveland, OH, United States; 2Department
of Radiology, Case Western Reserve University/University Hospitals,
Cleveland, OH, United States
In
this work, Time resolved angiography WIth Stochastic Trajectories (TWIST)
accelerated with parallel imaging, partial Fourier acquisition and view
sharing, was used to obtain simultaneous angiography and dynamic contrast
enhanced (DCE) perfusion measurements in muscle with a single contrast dose.
Parameter optimization was performed to select combinations of undersampling
schemes that provided the best temporal resolution while still limiting
artifact power and error in perfusion measurements. The results were used to
obtain MRA and perfusion exams on volunteer lower extremities during rest and
exercise, demonstrating the ability of the technique to measure physiological
perfusion changes.