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Abstract #2740

Parameter Optimization and Demonstration of Simultaneous Time Resolved Angiography and Perfusion Measurement in the Lower Extremities at Rest and with Exercise

Katherine L. Wright1, Nicole Seiberlich2, Stephen R. Yutzy1, Raymond F. Muzic1,2, Mark A. Griswold1,2, Vikas Gulani2

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Department of Radiology, Case Western Reserve University/University Hospitals, Cleveland, OH, United States

In this work, Time resolved angiography WIth Stochastic Trajectories (TWIST) accelerated with parallel imaging, partial Fourier acquisition and view sharing, was used to obtain simultaneous angiography and dynamic contrast enhanced (DCE) perfusion measurements in muscle with a single contrast dose. Parameter optimization was performed to select combinations of undersampling schemes that provided the best temporal resolution while still limiting artifact power and error in perfusion measurements. The results were used to obtain MRA and perfusion exams on volunteer lower extremities during rest and exercise, demonstrating the ability of the technique to measure physiological perfusion changes.