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Abstract #2742

Simultaneous Characterization of the Tumor Vascular Permeability, Vessel Size and Density by Using First-Pass Function/ Structure MR Imaging

Chia-Ming Shih1,2, Chien-Yuan Lin2, Chih-Yuan Chen2, Ta-Wei Chou2, Sui-Shan Lin2, Cheng-Hung Chou2, Yen-Yu Shih2, Jyh- Horng Chen1, Chen Chang2

1Institute of Biomedical Electronics and Bioinformatics, National Taiwan Unversity, Taipei, Taiwan; 2Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan

Two different contrast agents with different approaches were needed for assessing the vascular permeability and structure including vessel size and vessel density. In the present study, First-Pass Function/Structure MR Imaging (First Pass F/S MRI) technique was proposed to simultaneously evaluate vascular function and structure. The proposed technique can reduce scan time and assess the correlation between functional and structural changes in brain tumor.