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Abstract #2743

In Vitro Validation of Permeability-Surface Area Product Derived by Distributed Parameter Model with DCE-MRI

Septian Hartono1,2, Choon Hua Thng1, Tong San Koh2, Puor Sherng Lee1, Fang Keang Lim1, Theng Boon Lee1, Helmut Rumpel3, Quan Sing Ng1

1National Cancer Centre Singapore, Singapore, Singapore; 2Nanyang Technological University, Singapore, Singapore; 3Singapore General Hospital, Singapore

Hollow Fiber Bioreactors (HFBs), typically used for cell culture, mimicks well the human capillary system and thus is ideal to be used to validate the microcirculatory parameters obtained by tracer kinetic modeling. The aim of this study is to validate the permeability-surface area product (PS) obtained by tracer kinetic models with DCE-MRI in a HFB. Linear relationship was found between PS derived from the tracer kinetic models and pore size area of the HFBs.