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Abstract #2745

Quantitative Dynamic 19F MRI Oximetry in a Phantom Simulating Hypoxia

Steven H. Baete1,2, Yves De Deene1,2

1Laboratory for Quantitative Nuclear Magnetic Resonance in Medicine and Biology, ECNURAD, Ghent University, Ghent, Belgium; 2MEDISIP-IBBT, Ghent University, Ghent, Belgium

Tumor hypoxia is well known to reduce cancer treatment efficacy. Fluor-19 MRI oximetry can be used to map oxygen concentrations in hypoxic tissue. In this study a reproducible phantom which mimics oxygen consuming tissue is used for quantitative dynamic fluor-19 MRI oximetry. The phantom consists of a hemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells and perfluorocarbon vesicles which simulate the absorption of perfluorocarbons from intravenous emulsions in tissue. The phantom can be used for hypoxia simulations and for validating computational biophysical models of hypoxia, as measured with fluor-19 MRI oximetry.