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Abstract #2746

Detection of Skeletal Muscle Perfusion Differences with DCE-MRI: Contrast Agent and Pharmacokinetic Model

Karolien Jaspers1,2, Tim Leiner1,2, Petra Dijkstra3, Marlies Oostendorp1,2, Jolanda MCG van Golde4, Mark J. Post1,5, Walter H. Backes1,2

1Cardiovascular Research Insitute Maastricht, Maastricht, Netherlands; 2Radiology, Maastricht University Medical Centre, Maastricht, Netherlands; 3Central Animal Facilities, Maastricht University, Maastricht, Netherlands; 4Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands; 5Physiology, Maastricht University, Maastricht, Netherlands

Adequate introduction of therapeutic neovascularization in patients with peripheral arterial disease requires functional monitoring of vascular responses. The potential of the medium-sized contrast agent Gadomer for detecting (patho-) physiological perfusion differences with DCE-MRI was tested in a rabbit hind limb ischemia model. The lower extravasation rate of Gadomer requires a pharmacokinetic model that includes the blood plasma fraction vp rather than a model that accounts for reflux. Gadomer proved equally successful as Gd-DTPA in detecting flow differences between red (soleus) and white (tibialis) muscle, and between ischemic and normal soleus muscle tissue, while facilitating better image quality.