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Abstract #2753

A General Dual-Bolus Approach for High Resolution Quantitative DCE-MRI

Lucy Elizabeth Kershaw1, Marine Beaumont1, Hai-Ling Margaret Cheng1,2

1The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Department of Medical Biophysics, The University of Toronto, Toronto, Ontario, Canada

This study presents a dual-bolus technique to measure the arterial input function (AIF) for DCE-MRI. A low-dose prebolus was used to estimate the AIF for a tissue uptake curve measured from a second high-dose injection. AIFs were measured in the rabbit aorta using a high temporal resolution TRICKS acquisition. The scaled prebolus AIF was shown to match the main bolus AIF closely. Measurement of the AIF in a separate acquisition allows the tissue of interest to be imaged at high spatial resolution in a DCE-MRI experiment.