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Abstract #2760

Metabolic Changes in Luminal-Like Orthotopic Breast Cancer Xenografts Following Estrogen Supplement Withdrawal

Siver Andreas Moestue1, Vickie Yi Zhang2, Else Marie Huuse1, Beathe Sitter1, Gunhild Mari Mlandsmo3, Olav Engebrten3, Ingrid Susann Gribbestad1

1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Department of Radiology and Biomedical Imaging, UCSF, San Francisco, United States; 3Department of Tumor Biology, Institute for Cancer Research, Oslo, Norway

An estrogen-dependent luminal-like breast cancer xenograft model was used to study choline metabolites after endocrine therapy using HR MAS MRS. The data suggested that choline metabolite concentrations do not change following endocrine therapy wheras taurine and lactate do change.