Christopher S. Ward1, Sabrina M. Ronen1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States
CTP:choline-phosphate cytidylyltransferase (CCT) is the enzyme responsible for catalyzing the addition of CTP to phosphocholine to form CDP-choline, which is generally accepted to be the rate-limiting reaction in the formation of phosphatidylcholine. This study introduces a dynamic 31P MR-based means to measure the kinetics of the cytidylyltransferase-catalyzed reaction. The results suggest the potential of this technique to quantitatively assess modulations in CCT activity.