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Abstract #2771

Metabolic Changes Associated with HPV Infection in Cancer Cells Observed with 1H MRS

Dominik Zietkowski1, Geoffrey S. Payne1, Nandita M. deSouza1

1CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom

This study investigates the metabolic effects of HPV infection and tests whether 1H MRS can detect these in a model consisting of isogenic HPV-16 E6 transfected derivatives of A2780 ovarian cell line (E6 is the key cancer-causing HPV protein). It was possible to observe in the HPV-E6 transfects higher cholines, lower lactate, glycine, lipids and their (poly-) unsaturation. These changes seem to be related to changes in E6 transfects proliferation. Similar changes may also apply to HPV infection in cervix and documenting these may provide insights to understand the metabolic field effect observed around cervical tumor and into viral oncogenesis.