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Abstract #2775

Adjustible Curie-Temperature Nanoparticles for Imaging and Highly Controllable Hyperthermia Cancer Therapy

Boris Odintsov1, Vadim Aleksandrovich Atsarkin2, Viktor Demidov3, Andrey Kaul4, Mariya Popova4, Carolina Soto5, Edward Roy6

1Biomedical Imaging Center, University of Illinois , Urbana-Champaign, IL, United States; 2IRE RAN, Moscow, Russian Federation; 3IRE RAN, Russian Federation; 4Moscow University, Russian Federation; 5UIUC, IL, United States; 6University of Illinois, Urbana-Champaign, IL, United States

New nanomaterials recently synthesized in our group are lanthanum manganite doped with silver ions. The unique feature of the doped manganites is the possibility to control their Curie temperature in the range of tumor hyperthermia interest (41-43oC). At its Curie temperature, a ferromagnetic particle loses its magnetic properties; this metal-insulator phase transition is tunable and reversible. New ferromagnetic particles adopt the superparamagnetic behavior and are comparable to iron oxide as an MRI contrast agents. The goal of this presentation is to introduce newly synthesized nanomaterials and create a new platform for highly controllable hyperthermia cancer therapy and imaging.