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Abstract #2776

High Resolution MRI of Tumors in the Smo/Smo Mouse Medulloblastoma Model

Donghoon Lee1, Stacey Hansen2, Richard Ellenbogen1, Miqin Zhang1, James Olson2

1University of Washington, Seattle, WA, United States; 2Fred Hutchinson Cancer Research Center, Seattle, WA, United States

This work describes MRI methods for diagnosis and staging of tumors in the Smo/Smo genetically engineered mouse model of medulloblastoma. High resolution MRI was performed to attain T2 weighted imaging to screen tumors, T1 weighted imaging to examine the blood brain barrier integrity, and diffusion weighted imaging to improve tumor delineation. Sub-millimeter sized tumors in mice as young as 2 months were imaged even though animals were asymptomatic by other criteria. MRI findings were well correlated with histopathology. Thus, high resolution MR imaging is an excellent way to detect and stage tumors in mouse medulloblastoma models.