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Abstract #2780

Multi-Modal Assessment of Longitudinal Growth of Liver Metastases in a Mouse Model of Colon Carcinoma

Prachi Pandit1,2, Samuel M. Johnston1,2, Yi Qi2, Jennifer Story3, Beth Hollister3, G A. Johnson1,2

1Biomedical Engineering, Duke University, Durham, NC, United States; 2Center for In Vivo Microscopy, Duke University, Durham, NC, United States; 3Piedmont Research Center, Morrisville, NC, United States

In this work we present a longitudinal, multi-modality study to monitor the growth of liver metastases in mouse model of colon carcinoma. We have compared the relative merits of using high-field T2-weighting MRI and contrast-enhanced microCT as a preclinical cancer imaging technique in free-breathing mice. The advantages of microCT lie in the fast acquisition of high-resolution isotropic datasets. MRI, on the other hand has higher contrast resolution, and requires neither contrast injection nor radiation dose. Both techniques, ungated MRI and respiratory-gated MicroCT, perform well in the presence of motion, and are sufficiently fast and non-invasive to allow repeated scanning.