Prachi Pandit1,2, Samuel M. Johnston1,2,
Yi Qi2, Jennifer Story3, Beth Hollister3, G
A. Johnson1,2
1Biomedical Engineering, Duke
University, Durham, NC, United States; 2Center for In Vivo
Microscopy, Duke University, Durham, NC, United States; 3Piedmont
Research Center, Morrisville, NC, United States
In
this work we present a longitudinal, multi-modality study to monitor the
growth of liver metastases in mouse model of colon carcinoma. We have
compared the relative merits of using high-field T2-weighting MRI and contrast-enhanced
microCT as a preclinical cancer imaging technique in free-breathing mice. The
advantages of microCT lie in the fast acquisition of high-resolution
isotropic datasets. MRI, on the other hand has higher contrast resolution,
and requires neither contrast injection nor radiation dose. Both techniques,
ungated MRI and respiratory-gated MicroCT, perform well in the presence of
motion, and are sufficiently fast and non-invasive to allow repeated
scanning.
Keywords