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Abstract #2781

Imaging of Tumor Angiogenesis in a Novel Skin Chamber Using MRI and Optical Imaging

Tobias Buerle1, Clarissa Gillmann2, Reiner Umathum1, Margareta M. Mller3, Michal Neeman4, Wolfhard Semmler2, Michael Bock1

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, Germany; 2Medical Physics in Radiology, German Cancer Research Center , Heidelberg, Germany, Germany; 3Tumor- and Microenvironment, German Cancer Research Center, Heidelberg, Germany, Germany; 4Biological Regulations, The Weizmann Institute of Science, Rehovot, Israel


Tumor angiogenesis in animal models is often visualized using optical imaging or MRI. In this work we present a subcutaneous skin chamber for simultaneous optical and MR imaging to study the tumor-induced growth of blood vessels in vivo. The fully MR-compatible chamber features an optical window, and can be combined with a dedicated external loop coil.