Maria Tunset Grinde1, Siver Andreas Moestue1, ystein Risa1, Olav Engebraaten2, Ingrid Susann Gribbestad1
1Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway; 2Department of Tumor Biology, Cancer Research Institute, Oslo University Hospital, Oslo, Norway
13C HR MAS MR spectroscopy has been used to study two breast cancer xenograft models, representing a human luminal-like and a basal-like genetic profile. The models received a bolus injection of [1-13C]glucose and the conversion from glucose to lactate and alanine was observed 10 or 15 minutes after. The luminal-like model showed a significantly lower ratio of glucose/alanine and glucose/lactate compared to the basal-like model. This can be explained by a lower uptake of glucose and/or a higher rate of glucose metabolism towards alanine and lactate in the luminal-like compared to the basal-like model.