Teresa
Delgado-Goni1,2, Rui V. Simoes, 12, Milena Acosta,
12, Juana Martin-Sitjar1,2, Silvia Lope-Piedrafita, 2,3,
Carles Arus1,2
1Bioquimica
i Biologia Molecular, Universitat Autonoma of Barcelona, Cerdanyola del
Valles, Barcelona, Spain; 2CIBER-BBN, Zaragoza, Spain; 3Servei
de Ressonancia Magnetica Nuclear, Universitat Autonoma of Barcelona,
Cerdanyola del Valles, Barcelona, Spain
We
describe here the application of Dimethyl Sulfoxide (DMSO) as a potential
contrast agent for brain tumour imaging. DMSO crosses the
blood-brain-barrier, but its differential wash-out kinetics produces a clear
contrast enhancement in mouse brain glioblastoma compared to
nearby/peritumoral brain parenchyma, measured by SV MRS and MRSI sequences.
Keywords