Else Marie Huuse1, Siver Andre Moestue1,
Olav Engebrten2,3, Tone Frost Bathen1, Ingrid Susann
Gribbestad1
1Department of Circulation and Medical
Imaging, Norwegian University of Science and Technology (NTNU), Trondheim,
Norway; 2Department of Tumor Biology, Institute for Cancer
Research, Oslo, Norway; 3Oslo University Hospital , Oslo, Norway
Molecular
sub-classification of breast cancer based on gene expression pattern
represents clinically distinct patient groups with different outcome. Two
breast cancer xenograft models reflecting two of these groups: Basal like
(ER-, poor prognosis) and luminal like (ER+, better prognosis), were
characterized using DCE-MRI. Our results shows a significant higher Ktrans in
basal like than in luminal like small tumors, however, this difference
disappears for large tumors. Estradiol withdrawal had minor effect on growth
and DCE-MRI derived parameters for the basal like tumors. The luminal like
tumors ceased to grow and had a significant increase in Ktrans and ve .
Keywords