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Abstract #2789

Dynamic Contrast-Enhanced Magnetic Resonance Imaging Reveals Differences in Xenografts with Luminal Like and Basal Like Gene Expression Pattern

Else Marie Huuse1, Siver Andre Moestue1, Olav Engebrten2,3, Tone Frost Bathen1, Ingrid Susann Gribbestad1

1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 2Department of Tumor Biology, Institute for Cancer Research, Oslo, Norway; 3Oslo University Hospital , Oslo, Norway

Molecular sub-classification of breast cancer based on gene expression pattern represents clinically distinct patient groups with different outcome. Two breast cancer xenograft models reflecting two of these groups: Basal like (ER-, poor prognosis) and luminal like (ER+, better prognosis), were characterized using DCE-MRI. Our results shows a significant higher Ktrans in basal like than in luminal like small tumors, however, this difference disappears for large tumors. Estradiol withdrawal had minor effect on growth and DCE-MRI derived parameters for the basal like tumors. The luminal like tumors ceased to grow and had a significant increase in Ktrans and ve .