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Abstract #2799

Improving Suspicious Breast Lesion Characterization Using Lesion Fractional Volume Washout Kinetic Analysis

Jie Huang1, Lori Hoisington1, Sarah Schafer1, Xiaopeng Zong1, Kevin Berger1

1Department of Radiology, Michigan State University, East Lansing, MI, United States

This study investigated using lesion fractional volume washout (WO) kinetic analysis for improving the characterization of suspicious contrast-enhancing breast lesions. The WO volume fraction was found to be significantly different between the biopsy-proven benign and malignant lesions of all the suspicious breast lesions with BI-RADS assessment of 4 or 5. It showed a potential to improve the positive predictive value of the biopsies by an improvement rate of 86.8%, and consequently would yield a 72.2% reduction rate to the total number of unnecessary biopsies.