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Abstract #2800

Qualitative and Quantitative Assessment of Breast Tumour Appearance in Diffusion-Weighted Imaging and Correlation with Molecular Prognostic Factors

Giuseppe Petralia1, Luke Bonello1, Paul Summers1, Sara Raimondi2, Ala Malasevschi1, Roberto Di Filippi1, Dow-Mu Koh3, Marzia Locatelli4, Giuseppe Curigliano4, Massimo Bellomi1

1Radiology, Istituto Europeo di Oncologia, Milan, Lombardia, Italy; 2Epidemiology and Biostatistics, Istituto Europeo di Oncologia, Milan, Lombardia, Italy; 3Radiology, Royal Marsden Hospital, Sutton, United Kingdom; 4Medical Oncology, Istituto Europeo di Oncologia, Milan, Lombardia, Italy

We performed a qualitative analysis of diffusion weighted magnetic resonance imaging (DW-MRI) of breast tumours to identify common semiotic characteristics, and a quantitative analysis in 28 patients to examine the correlation of DW-MRI with molecular prognostic factors, and to assess the interobserver variability in the calculation of ADC values. Hyper-intensity in DW images and low ADC values (mean 1.1 x 10-3mm2/sec) were common characteristics in the breast tumours studied. Interobserver variability was 20%.A marginally significant correlation between ADC value and percentage of PgR and possible higher mean ADC values for the LUMINAL A subtype warrant further study.