Jrg Dpfert1, Andreas Lemke1, Anja Weidner2, Lothar Rudi Schad1
1Department of Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2Institute of Radiology and Nuclear Medicine, Heidelberg University, Mannheim, Germany
In this work, the decrease of the apparent diffusion coefficient (ADC) in cancerous prostate tissue compared to healthy prostate tissue is investigated using the Intravoxel Incoherent Motion (IVIM) Theory. Moreover , the extracted parameters and the calculated parameter maps are analyzed with regard to the differentiation between cancerous and healthy tissue. Therefore, diffusion weighted images of the prostate of 9 patients with prostate carcinoma were acquired and evaluated, yielding a significant decrease of the ADC and the perfusion fraction in cancerous tissue compared to healthy tissue. The results suggest that the decrease of the ADC primarily comes from perfusion effects.