Piotr Kozlowski1,2, Silvia D. Chang2,
Edward C. Jones3, Ran Meng1, Nicholas Buchan4,
S Larry Goldenberg, 4,5
1UBC MRI Research Centre, Vancouver,
BC, Canada; 2Radiology, Univeristy of British Columbia, Vancouver,
BC, Canada; 3Pathology and Laboratory Medicine, Univeristy of
British Columbia, Vancouver, BC, Canada; 4Vancouver Prostate
Centre, Vancouver, BC, Canada; 5Urologic Sciences, Univeristy of
British Columbia, Vancouver, BC, Canada
DTI
and DCE MRI were carried out in 27 prostate cancer patients. Mean
diffusivity, fractional anisotropy and pharmacokinetic modeling parameters
calculated from MRI data were correlated with Gleason score determined by
biopsy and prostatectomy specimens. Mean diffusivity and fractional
anisotropy correlated significantly with Gleason score, as demonstrated by
the Spearmans rank correlation test and the ordinal logistic regression
modelling. These results strongly suggest that DTI MRI is capable of
non-invasively grading prostate tumours.
Keywords