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Abstract #2814

Clinical Prostate T2 Quantification Using a Magnetization-Prepared Spiral Technique

Warren Foltz1, Supriya Chopra1, Peter Chung1, Andrew Bayley1, Charles Catton1, David Jaffray1, Graham Wright2, Masoom Haider3,4, Cynthia Mnard1

1Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada; 2Sunnybrook Research Institute, Toronto, Ontario, Canada; 3Medical Imaging, University Health Network, Toronto, Ontario, Canada; 4Medical Imaging, University of Toronto

A magnetization-prepared spiral imaging technique, termed T2prep, was adapted for robust time-efficient clinical prostate evaluation, and piloted in two prostate cancer cohorts. The patient groups presented with: (A) no prior history of external beam radiation; and (B) biochemical failure after radiotherapy. Cohorts were scanned (A) without and (B) with an endo-rectal coil in tandem with a torso phased-array, respectively. Prostate zonal and tumor T2 values supported known trends. For each cohort, an SNR analysis was performed to identify minimum region volumes for thermal-noise insensitive measurements, and to guide protocol design for future voxel-based anlaysis.