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Abstract #2857

B1 Insensitive Genetically Altered Refocusing Pulses for Ultrahigh Field Spin Echo Imaging

Aaron Christopher Hurley1,2, Andrew Peters1, Uwe Aickelin2, Li Bai2, Penny Anne Gowland1

1SPMMRC, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Computer Science, University of Nottingham, United Kingdom

Urgurbil et al. proposed the use of a Numerically Optimised Modulation (NOM) scheme to improve the adiabaticity over the whole length of a BIR4 pulse and this method provides better performance for shorter pulses. NOM resamples the AM and FM functions with reference to the adiabatic condition and is restricted to looking at on-resonance effects. Following from this work, we attempted to optimize the resampling function via a Genetic Algorithm. The evaluation function considers B1 and B0 inhomogeneities to tailor the optimization to 7T conditions, requiring the study of off-resonance behaviour.