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Abstract #2967

Water-Specific Quantitative MRI Relaxometry of the Brain Using Spatial-Spectral Water Excitation: Preliminary Experience

Stephan William Anderson1, Jorge A. Soto1, Osamu Sakai1, Hernan Jara1

1Radiology, Boston University Medical Center, Boston, MA, United States

The purpose of this work was to test a pulse sequence for spatial- and spectral-selective qMRI relaxometry in vivo for deriving qMRI parameters in brain imaging. The brain of a volunteer was imaged using both non-chemically selective mixed-TSE sequence as well as the SSE-mixed-TSE pulse sequence to derive parametric maps of PD, T1, T2 (including secular-T2), and ADC of the brain. T2 was found to be consistently longer for the SSE-mixed-TSE pulse sequence. Spectrally selective qMRI may offer insight into both normal structures as well as pathology without the confounding effects of lipids.