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Abstract #2981

Pulsed CEST for the Quantification of PH

Kimberly Lara Desmond1, Greg J. Stanisz1,2

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

We present a method for the quantification of pH using a pulsed chemical exchange saturation transfer (CEST) method. Experimental data is from a phantom model consisting of 1M ammonium chloride in 10mM citric acid buffer for the modification of pH. This data is fit using a two-compartment Bloch equation model of exchange in the presence of off-resonance excitation. A linear relationship is observed between the log of the fitted exchange rate and the true pH of the phantom.