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Abstract #3137

Quantitative and Local Mouse Brain Morphometry in Longitudinal MRI Studies

Alize Elske Hiltje Scheenstra1, Dana Suciu2, Michael Muskulus3, Melly S. Oitzl4, Johan H.C. Reiber1, Louise van der Weerd5, Jouke Dijkstra1

1Radiology, image processing, LUMC, Leiden, Netherlands; 2Radiology, LUMC, Leiden, Netherlands; 3Mathematical Department, Leiden University, Leiden, Netherlands; 4LACDR, Leiden University, Netherlands; 5Department of Anatomy and Embryology, LUMC, Leiden, Netherlands

We present the Moore-Rayleigh (MR) test as nonparametric statistical test for longitudinal brain MRI deformation based morphometry: A group of male mice (n=10) was followed during exposure to the stress hormone hormone corticosterone for 2 weeks and a recovery period of 1 week. The results of the MR test are comparable to volumetric based morphometry, but it enriches the analysis with its ability to detect also localized shape changes, which are still significant under Bonferroni correction.