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Abstract #3138

Type I Errors in Whole Brain Voxel-Wise Analyses

David Matthew Carpenter1, Cheuk Ying Tang1,2

1Radiology, Mount Sinai School of Medicine, New York, United States; 2Psychiatry, Mount Sinai School of Medicine, New York, NY, United States

Voxel based analysis or Statistical Parametric Mapping (SPM) yields inconsistent results across studies. It is difficult to challenge the validity of SPM results in published works and review submissions because the nature of the immense datasets that underlie VBA results prohibits its presentation in journals. In this abstract we use a simple data set to explore sources of type I errors in areas that often yield positive results and present findings that can serve as a guide for critiquing these SPM presentations.