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Abstract #3141

Developmental Changes in the Shape of Hippocampus in Children Aged from 6 to 9 Years Old

Muqing Lin1, Lutfi Tugan Muftuler1, Ke Nie1, Kevin Head1, Claudia Buss2, Elysia Poggi Davis2, Curt A. Sandman2, Orhan Nalcioglu1, Min-Ying Lydia Su1

1Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, Irvine, CA, United States; 2Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, United States

The shape analysis of hippocampus was commonly applied to evaluate the progression of atrophy pattern in elderly patients, and in this study it was applied to evaluate the changes in developmental brain in 48 children. The distance from the hippocampal surface to the central line was mapped to a 2D grid for statistical analysis. The Permutation and t-test was applied to compare two age groups (6-7 vs. 8-9 y/o), and the regression analysis with age was also performed. Significant differences were found in small areas of CA1 and subiculum; however, overall there is not a strong age dependence.