Muqing Lin1, Lutfi Tugan Muftuler1,
Ke Nie1, Kevin Head1, Claudia Buss2, Elysia
Poggi Davis2, Curt A. Sandman2, Orhan Nalcioglu1,
Min-Ying
1Tu & Yuen Center for Functional
Onco-Imaging, University of California, Irvine, Irvine, CA, United States; 2Department
of Psychiatry and Human Behavior, University of California, Irvine, Irvine,
CA, United States
The
shape analysis of hippocampus was commonly applied to evaluate the progression of atrophy pattern in elderly
patients, and in this study it was
applied to evaluate the changes in developmental brain in 48 children. The distance from the hippocampal
surface to the central line was mapped
to a 2D grid for statistical analysis. The Permutation and t-test was applied to compare two age
groups (6-7 vs. 8-9 y/o), and the
regression analysis with age was also performed. Significant differences were found in small areas of
CA1 and subiculum; however, overall
there is not a strong age dependence.
Keywords