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Abstract #3173

Sodium MRI: A Reproducibility Study in Subjects with Osteoarthritis of the Knee

Laurence D. Toms1, Rexford D. Newbold1, Anil Rao1, Sam R. Miller2, Jeroen A. Tielbek1, Mark D. Tanner1, Ros M. Gordon1, Robin K. Strachan3, Paul M. Matthews1, Andrew P. Brown1

1GlaxoSmithKline Clinical Imaging Centre, Imperial College, Hammersmith Hospital, London, United Kingdom; 2Discovery Analytics, GlaxoSmithKline, Harlow, United Kingdom; 3Department of Orthopaedic Surgery, Imperial College Healthcare NHS Trust, London

Sodium imaging in articular cartilage may be an indicator of osteoarthritis progression. In this work we sought to assess the reproducibility of this technique. Using a dual tuned 1H/23Na quadrature volume coil, 3D DESS proton images and 3D-cones short echo time sodium images were acquired in the same scan session, which was repeated for 11 subjects. DESS images were segmented, and the resulting ROIs were applied to the co-registered sodium images. The technique showed good repeatability: the interclass correlation coefficient for sodium was 0.88 (0.6 0.97) and the percent coefficient of variation was 4.2% (2.9%-7.3%).