Kelsey Mairead Mountain1,2, Tadeusz Foniok3,
Jeff Dunn, 1,3, John Robert Matyas, 2,4
1Biomedical Engineering, University of
Calgary, Calgary, Alberta, Canada; 2McCaig Institute for Bone and
Joint Health, Calgary, Alberta, Canada; 3National Research Council
Canada, Calgary, Alberta, Canada; 4Faculty of Veterinary Medicine,
University of Calgary, Calgary, Alberta, Canada
The
superficial zone of articular cartilage is a dense network of ordered
collagen fibres running parallel to the articular surface. The initial
histopathological changes of osteoarthritis (OA) occur at this surface; and
if detected, could provide insight into OA progression. High-field MRI can
detect collagen organization based on changes in T2 relaxation. In this
study, T2 was used to assess articular cartilage surface collagen in an
animal model of osteoarthritis.
Keywords