Kelsey Mairead Mountain1,2, Tadeusz Foniok3, Jeff Dunn, 1,3, John Robert Matyas, 2,4
1Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada; 2McCaig Institute for Bone and Joint Health, Calgary, Alberta, Canada; 3National Research Council Canada, Calgary, Alberta, Canada; 4Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
The superficial zone of articular cartilage is a dense network of ordered collagen fibres running parallel to the articular surface. The initial histopathological changes of osteoarthritis (OA) occur at this surface; and if detected, could provide insight into OA progression. High-field MRI can detect collagen organization based on changes in T2 relaxation. In this study, T2 was used to assess articular cartilage surface collagen in an animal model of osteoarthritis.