Meeting Banner
Abstract #3190

The Transport of Anionic and Nonionic MRI Contrast Agents Into Human Hip Cartilage

Eveliina Lammentausta1, Samo Lasic2, Daniel Topgaard2, Olle Sderman2, Leif E. Dahlberg3

1Department of Clinical Sciences, Malm, Joint and Soft Tissue Unit, University of Lund, Malm, Sweden; 2Department of Physical Chemistry, University of Lund, Lund, Sweden; 3Department of Orthopaedics, Malm University Hospital, Malm, Sweden

The aim of the study was to investigate the distribution of ionic and non-ionic contrast agent in human hip cartilage. T1 relaxation time of osteochondral plugs were measured before and regularly after the exposure to the contrast agent until ten hours. Significant difference between the two contrast agents was observed. The amount of ionic contrast agent was considerably smaller compared to non-ionic, especially in deep cartilage. Ionic contrast agent reached equilibrium, whereas the amount of non-ionic contrast agent kept increasing even after ten hours. This suggests that maximum uptake of ionic contrast agent is controlled by the properties of cartilage.