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Abstract #3189

Age Dependent Modulation of Aggrecan in Human Knee Cartilage Measured Via Sodium MRI at 7T

Victor Babu Kassey1, Adam Shore1, Hari Hariharan1, Ganapathy Ramanathan1, Sonia N. Vallespin2, Thomas Connick1, Anup Singh1, Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Cardiovascular MR Unit, Royal Brompton and Harefield NHS Foundation Trust, Chelsea, London, United Kingdom

In the present work, we determined the age dependent variation of molecular changes in human knee cartilage via sodium MRI at ultrahigh fields. Aggrecan has been shown to undergo predominant change in early OA. More than 80% of population over 65 years of age experience pain due to knee OA. Using sodium MRI, we investigated the natural, age dependent molecular changes in the healthy human knee cartilage in vivo. These preliminary results demonstrate that it is feasible to obtain sodium maps of human knee in-vivo at 7T and quantify age dependent molecular changes in knee cartilage of healthy human subjects.