Gregory
Chang1, Klaus M. Friedrich2, Ligong Wang3,
Graham C. Wiggins3, Michael Recht, Guoyuan Liang4,
Punam K. Saha5, Ravinder R. Regatte3
1Radiology, NYU Langone Medical Center,
New York, NY, United States; 2Radiology, Medical University of
Vienna, Austria; 3Radiology, NYU Langone Medical Center, New York,
United States; 4Electrical and Computer Engineering, Iowa City,
IA, United States; 5Radiology and Electrical & Computer
Engineering, Iowa City, IA, United States
In
this study, we performed a regional and subregional quantitative assessment
of trabecular bone micro-architecture of the knee in subjects with
osteoarthritis (OA) using high spatial resolution MRI at 7 Tesla. OA subjects demonstrated decreases in numerous
parameters of trabecular bone morphology and topology compared to healthy
controls. Subregional analyses within
the medial femoral condyle, lateral femoral condyle, medial tibial plateau,
and lateral tibial plateau allowed the detection of smaller geographic areas
of abnormal trabecular bone micro-architecture in OA subjects. This technique may allow more accurate
characterization of the spatial distribution of the pathologic changes in the
osteoarthritic knee.
Keywords