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Abstract #3198

Diffusion Tensor Imaging (DTI) as a Probe to Measure Trabecular Bone Orientation In-Vivo

Bailiang Chen1, Pierre-Andr Vuissoz2,3, Amaka Offiah4, Martin Fry1, Andrew Todd-Pokropek1

1Medical Physics and Bioengineering, University College London, London, United Kingdom; 2IADI, Nancy-Universit, Nancy, France; 3U947, INSERM , Nancy, France; 4Academic Unit of Child Health, Sheffield Children's NHS Foundation Trust, Sheffield, United Kingdom

Trabecular bone orientation, together with bone mineral density, plays an important role in evaluating bone quality. This structural information is also a key parameter in bridging bone mechanical behaviour at a macro-scale and its functional adaptation at a cellular scale. Trabecular bone can be considered as a typical porous media. Through anisotropic diffusion within red marrow, DTI can be used as a probe of trabecular bone orientation in-vivo. Here, we present the current results of our in-vivo studies applying DTI to human tibia, its reproducibility and the techniques ability to reveal trabecular network orientation at a micro-scale.