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Abstract #3201

Assessment of Bone Marrow Oxygenation Based on T2* and T2 Changes Following Oxygen Inhalation

David K W Yeung1, James F. Griffith1, Yi-xiang Wang1, Jing Yuan1, Queenie Chan2, Heather T. Ma1

1Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 2MR, Philips Healthcare, Wanchai, Hong Kong

Marrow mesenchymal stem cells can differentiate along osteoblastic, adipocytic or haematopoietic cell lines. Whether a shift occurs in stem cells differentiation in osteoporosis is unknown. Iron-rich red marrow influences T2* and fat-rich yellow marrow affects T2. Our goal was to verify whether breathing oxygen may reduce the amount of deoxyhemoglobin (paramagnetic) in marrow constituents thereby prolonging both T2* and T2. Our results showed that, for the first time, both T2* and T2 of bone marrow increased after oxygen inhalation. The larger δT2* compared to δT2 might reflects a higher oxygen demand in the red marrow than the yellow marrow.