Heather Ting Ma1,2, James Francis Griffith1,
David K. Yeung1, Ping-Chung Leung3
1Department of Diagnostic Radiology and
Organ Imaging, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 2Electronic
and Information Engineering Department, Harbin Institute of Technology
Shenzhen Graduate Shool, Shenzhen, Guang Dong, China; 3Jockey Club
Centre for Osteoporosis Care and Control, The Chinese University of Hong
Kong, Shatin, N.T., Hong Kong
Pharmacokinetic
model has been applied to the study of tumor angiogenesis providing
meaningful parameters of tissue physiology. Recently studies have applied
pharmokinetic principles to the study of marrow perfusion. This study used a
modified Brix model to investigate bone perfusion in osteoporosis.
Alternation in functional parameters related to bone perfusion has been
observed in subjects with varying bone mineral density. This study provided
quantitative data indicating a change in perfusion in osteoporosis. Further research
on the pharmacokinetic modeling specific on bone marrow increases our
understanding of the physiological and pathological changes in marrow
perfusion occurring in osteoporosis and other bone diseases.
Keywords