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Abstract #3207

Pharmacokinetic Modeling Study on Bone Perfusion of Osteoporosis

Heather Ting Ma1,2, James Francis Griffith1, David K. Yeung1, Ping-Chung Leung3

1Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 2Electronic and Information Engineering Department, Harbin Institute of Technology Shenzhen Graduate Shool, Shenzhen, Guang Dong, China; 3Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

Pharmacokinetic model has been applied to the study of tumor angiogenesis providing meaningful parameters of tissue physiology. Recently studies have applied pharmokinetic principles to the study of marrow perfusion. This study used a modified Brix model to investigate bone perfusion in osteoporosis. Alternation in functional parameters related to bone perfusion has been observed in subjects with varying bone mineral density. This study provided quantitative data indicating a change in perfusion in osteoporosis. Further research on the pharmacokinetic modeling specific on bone marrow increases our understanding of the physiological and pathological changes in marrow perfusion occurring in osteoporosis and other bone diseases.