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Abstract #3206

Ultra Short TE MRI as a Quantitative Measure of Bone Density?

Christina Messiou1, David Collins1, Matthew Robson2, Veronica Morgan1, Sharon Giles1, Catherine Parry-Jones1, Nandita deSouza1

1CRUK and EPSRC Cancer Imaging Centre, Department of Magnetic Resonace Imaging, Institute of Cancer Research/The Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 2Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

UTE MRI allows detection of signal from very short T2 tissue that previously returned no signal on conventional MR sequences. Preliminary data from this ongoing study suggests that there is a significant linear relationship between % change in T2* measured by UTE MRI and CT Hounsfield Units of sclerotic bone metastases, hence UTE MRI has potential to quantify changes in the sclerotic components of bone metastases. If the relationship of T2* with HU can be extrapolated to electron density this would allow much sought after radiotherapy planning using MR data and may also be a novel approach to attenuation correction for PET/MR.