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Abstract #3222

Quantitative Magnetization Transfer Ultrashort Echo Time Imaging of the Achilles Tendon.

Richard Hodgson1, Robert Evans2, Peter Wright2, Matthew Robson3

1Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, Yorks, United Kingdom; 2Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, Yorks, United Kingdom; 3Centre for Clinical Magnetic Resonance Research, Unversity of Oxford, Oxford, Oxfordshire, United Kingdom

Magnetization transfer in the Achilles tendon was investigated using ultrashort echo time imaging with off resonance saturation pulses (2-100kHz off resonance). The experimental data was fitted to a two-compartment model. Magnetization transfer effects were demonstrated which showed good agreement with the model. The bound water fraction from the model was consistently higher than that reported in white matter in the brain, reflecting the high collagen content in tendon. This technique appears feasible and and may be useful for assessing changes in collagen content which occur in tendonopathy.