1H-MRS to Evaluate Intramuscular Lipid Changes in HIV-Patients with Lipodystrophy Syndrome by LCmodel

Ana Isabel Garcia¹, Ana Milinkovic², Iaki Perez³, Xavier Tomas, Sergi Vidal-Sicart⁴, Carles Falcon⁵, Jaume Pomes, Montserrat Del Amo, Josep Mallolas²

1H-MR spectroscopy was performed to assess intramyocelullar lipids (IMCL) in a group of HIV-patients with lipodystrophy syndrome receiving stable antiretroviral therapy and their changes 6 months after switching the treatment. HIV-patients at baseline revealed higher IMCL than controls, although no significant. Statistical analysis revealed a significant reversal of peripheral lipoatrophy with decreased of the lean mass after switching the treatment, and it was related with IMCL decreased, although no significant. A probable migration of lipid content from intramyocellular to periphery can explain partially the peripheral fat gain and loss of peripheral lean mass, although other factors may participate.