Charles Qingchuan Li1, Weitian Chen2, Jarrett K. Rosenberg1, Philip J. Beatty2, Anja C. Brau2, Richard X. Kijowski3, Brian A. Hargreaves1, Reed F. Busse4, Garry E. Gold1
1Radiology, Stanford University, Stanford, CA, United States; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 3Radiology, University of Wisconsin, Madison, WI, United States; 4Global Applied Science Laboratory, GE Healthcare, Madison, WI, United States
A new isotropic 3D FSE sequence, 3D-FSE-Cube, is currently being developed for multiple structural imaging applications as an improvement to traditional 2D-FSE methods. This study aimed to optimize 3D-FSE-Cube for musculoskeletal evaluation of the knee at 3T. 146 scans from 7 healthy volunteers were acquired with systematically varied acquisition parameters and evaluated for SNR, CNR and image quality in comparison to a single reference standard. Regression analysis suggests that current clinical acquisition parameters produce close to optimal image quality.