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Abstract #3260

A DNP Polarizer Designed for Clinical Use

Andrew M. Leach1, John Urbahn1, Denise Anderson1, Neil Clarke2, Timothy Skloss3, Jan Henrik Ardenkjaer-Larsen2

1GE Global Research, Niskayuna, NY, United States; 2GE Healthcare, Amersham, United Kingdom; 3GE Healthcare, Waukesha, WI, United States

Provides a description of a novel hyperpolarizer design that incorporates specific characteristics required for clinical application including: 1) the ability to simultaneously process multiple doses; 2) no cryogen consumption; 3) a sterile product contained within a disposable fluid path; and 4) an integrated quality control system that rapidly measures six product characteristics to ensure agent safety and efficacy. The system has been demonstrated as a robust means to generate high volume doses for imaging studies. Device functionality and process capability will be discussed.