Andrew M. Leach1, John Urbahn1,
Denise Anderson1, Neil Clarke2, Timothy Skloss3,
Jan Henrik Ardenkjaer-Larsen2
1GE Global Research, Niskayuna, NY,
United States; 2GE Healthcare, Amersham, United Kingdom; 3GE
Healthcare, Waukesha, WI, United States
Provides
a description of a novel hyperpolarizer design that incorporates specific
characteristics required for clinical application including: 1) the ability
to simultaneously process multiple doses; 2) no cryogen consumption; 3) a
sterile product contained within a disposable fluid path; and 4) an
integrated quality control system that rapidly measures six product
characteristics to ensure agent safety and efficacy. The system has been
demonstrated as a robust means to generate high volume doses for imaging
studies. Device functionality and
process capability will be discussed.
Keywords